everything, even highly benign health undertakings like exercise have trade offs. these trade offs become critically important in mitigations such as vaccines that are going to be administered widely to healthy people. side effects that might well be acceptable to kill a cancer or delay the onset of diagnosed dementia suddenly look wildly inappropriate when one speaks of prophylaxis. barring some truly outlandish risk experience, pretty much no healthy person takes chemotherapy to try to avoid getting cancer. this is just sensible. it also means that the way we consider our terms and set up the buckets of our bayesian calculations matters a great deal.
Yes.
herd level antigenic fixation is not something humanity has ever grappled with before and that could be with us for a long time.
Yes with a hint of "Welp".